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Patrick Dempsey also auditioned for the part of Chase; he later became recognized for his portrayal of Dr. Derek Shepherd on Grey’s Anatomy. However, before her audition, Singer had watched some of her performances, including on Dawson’s Creek, and already needed to cast her in the position. Morrison left the show when her character was written out in the course House & Home Improvement news of season six. Individual episodes of the series contain further references to the Sherlock Holmes tales. The main patient in the pilot episode is called Rebecca Adler after Irene Adler, a personality within the first Holmes short story, “A Scandal in Bohemia”.